Synthesis, spectroscopic characterization and biological applications of Cu(II) and Ni(II) complexes with 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone.

Cu(II) and Ni(II) complexes of 2-butyl-4-chloro-5-formylimidazole thiosemicarbazone (L) are synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, mass spectrometry, electronic and EPR spectra. The complexes are found to have characteristic electronic spectra and the geometry of the complexes are identified as octahedron. Both the complexes are found to exhibit similar anti-microbial activity against the gram –ve and gram +ve bacteria. Anti-cancer activity against the cancer cell lines (MDA-MB 231 cell lines) among the compounds studied for % of viability, the inhibition concentration 50 values were shown by Cu(II)-L complex at 80 mg/ml and by Ni(II)-L complex at 100 mg/ml.

Synthesis, spectral aspects and biological activities of 5-hydroxy-2-nitrobenzaldehydethiosemicarbazone and their Mn(II), Co(II) and Ni(II) complexes.

The ligation behavior of 5-hydroxy-2-nitrobenzaldehydethiosemicarbazone (L) and its Mn(II), Co(II) and Ni(II) complexes has been synthesized and characterized by Elemental analysis, Electronic, FT-IR, Raman, EPR spectral techniques and Cyclic voltammetric study. The ligand (L) belongs to triclinic system with P1 space group. The IR spectral data of ligand indicate the taking part of sulphur and azomethine nitrogen in coordination to the central metal ion. The electronic, FT-IR and EPR spectral studies reveals all the complexes are distorted octahedral geometry. The synthesized ligand and its metal(II) complexes were tested for their antioxidant activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and antibacterial activity against E.coli, Staphylococcus aureus, Bacillus subtilis, Salmonella typhi and Klebsiella pneumonia. The antibacterial and antioxidant activities of the ligand and its metal complexes had shown moderate to good activity, among all the compounds Ni(II) complex had shown more activity.

Synthesis, spectroscopic characterization and antimicrobial activity studies of 2-Butyl-4-chloro-5-formylimidazole thiosemicarbazone and its manganese (II) complex.

A novel chelating tridentate organic ligand, 2-Butyl-4-chloro-5-formylimidazole thiosemicarbazone(L) is synthesized and characterized by using spectroscopic techniques like elemental analysis, FT-IR, 1H and 13C NMR, UV-vis and Mass spectrometry. The free ligand is then used for the synthesis of Mn(II) complex thoroughly characterized by FT-IR, EPR and electronic spectral analysis. The complex is found to have characteristic d5 electronic spectrum and the geometry of the complex is identified as octahedron based on the g value obtained from the EPR spectrum. Both the ligand and Mn(II)L2 compounds are found to exhibit similar antimicrobial activity against the gram –ve and gram +ve bacteria.

New Halogenated Thiosemicarbazones as Potential Antimicrobial Agents: synthesis and spectral characterization.

Three new chalcogenic thiosemicarbazones (3,4-difluoroacetophenone thiosemicarbazone(1), 2-bromo-4’- chloroacetophenone thiosemicarbazone(2) and 2, 4’-dibromoacetophenone thiosemicarbazone(3) are synthesized by using a conventional one step processes in which the respective halo-substituted acetophenones are condensed with thiosemicarbazide to result in the formation of the product. The chalcogenic thiosemicarbazones are then characterized by the spectroscopic techniques like FT-IR, FT-Raman, UV-Vis, 1H and 13C NMR (19F for 1), HRMS and LC-MS, TG-DTA. The compound 1 is unambiguously characterized by single crystal X-ray diffraction and is found to have monoclinic system. These compounds were further tested for their antimicrobial activity against some human pathogens like E. coli, B. subtilis, P. aureginosa and S. aureus. The MIC values have suggested that these are potential antimicrobial agents.